![]() 3 We therefore evaluated the longitudinal effects of visceral fat and the effect of its change on regression of erosive esophagitis. However, there are no data the effect of visceral fat on the regression of erosive esophagitis even if weight gain increased the risk of erosive esophagitis. 9 We firstly reported that high visceral fat and increase of visceral fat during follow-up induced new development of erosive esophagitis in a previous cohort study. 4 Recent cross-sectional studies also showed a strong relationship of abdominal visceral fat with erosive esophagitis 8 and Barrett’s oesophagus. 7 We previously demonstrated that abdominal visceral fat was a better predictor of reflux esophagitis than body mass index (BMI). 3– 5 Abdominal visceral fat contribute to GERD by mechanical disruption of the integrity of the gastroesophageal junction 6 and metabolic effects such as increasing inflammatory cytokines and the risk of cardiovascular disease. 1, 2 Many previous studies demonstrated the association between obesity and GERD. The prevalence of gastroesophageal reflux disease (GERD) according to increase of obesity has been increasing over the past decades in Korea. Keywords: Esophagitis, Intra-abdominal fat, Cohort studies Higher visceral fat at follow-up and a greater increase in visceral fat reduced the regression of erosive esophagitis in a dose-dependent manner. The presence of baseline Helicobacter pylori increased the regression of erosive esophagitis (RR, 2.40 95% CI, 1.05 to 5.48). Each trend showed a dose-dependent pattern (p for trend <0.001). The highest quartile of visceral fat change reduced the probability of the regression of erosive esophagitis compared to the lowest quartile (RR, 0.10 95% CI, 0.03 to 0.28). The 3rd (RR, 0.13 95% CI, 0.02 to 0.71) and 4th quartiles (RR, 0.07 95% CI, 0.01 to 0.38) of visceral fat at follow-up were associated with decreased regression of erosive esophagitis. Regression was observed in approximately 49% of participants (n=80). The longitudinal effects of abdominal visceral fat on the regression of erosive esophagitis were evaluated using relative risk (RR) and 95% confidence intervals (CIs). MethodsĪ total of 163 participants with erosive esophagitis at baseline were followed up at 34 months and underwent esophagogastroduodenoscopy and computed tomography at both baseline and follow-up. We evaluated the effects of abdominal visceral fat change on the regression of erosive esophagitis in a prospective cohort study. ![]() The editor retains the right to determine publication priorities, the style of the paper, and to request, if necessary, that the material submitted be shortened for publication.Īlthough abdominal visceral fat has been associated with erosive esophagitis in cross-sectional studies, there are few data on the longitudinal effect. In many cases, papers may be rejected despite favorable reviews because of editorial policy or a lack of space. The final responsibility for the decision to accept or reject lies with the editors. We reserve the right to return manuscripts in which no reviewers are suggested. We may not always use the reviewers you recommend, but suggesting reviewers will make our reviewer database much richer in the end, everyone will benefit. It would be very helpful if you could suggest a selection of reviewers and include their contact details. The remaining articles are usually sent to two reviewers. A decision about these papers will usually be made within two or three weeks. All papers submitted to Gut and Liver are reviewed by the editorial team before being sent out for an external peer review to rule out papers that have low priority, insufficient originality, scientific flaws, or the absence of a message of importance to the readers of the Journal.
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